Buy reliable Quality Doxepin hydrochloride 1229-29-4 raw material with Honest Price We provide high quality Doxepin hydrochloride (CAS 1229-29-4), at a very affordable prices to our customers.

1.What is the Doxepin hydrochloride ?

Doxepin is a tricyclic antidepressant that binds to the serotonin (5-HT) transporter (SERT) and norepinephrine transporter (NET; Kds = 68 and 29.5 nM, respectively). It is a histamine H1 receptor antagonist (Ki = 1.23 nM). Doxepin selectively binds to SERT and NET over the dopamine transporter (DAT; Kd = 12,100 nM) and inhibits histamine H1 over H2, H3, and H4 receptors (Kis = 170, 39,810, and 15,135 nM, respectively). It also binds to the 5-HT2 receptor, as well as to muscarinic acetylcholine and α1-adrenergic receptors (α1-ARs; Kds = 27, 23, and 23.5 nM, respectively). Doxepin (10 mg/kg, i.p.) decreases allodynia and hyperalgesia in a mouse model of chronic constriction injury-induced neuropathic pain. It increases the distance traveled in the center of the open field test and reduces immobility time in the forced swim test in a mouse model of depression induced by chronic stress when administered orally at a dose of 15 mg/kg. Formulations containing doxepin have been used in the treatment of depression and insomnia.

Doxepin (Sinequan, Adapin) is a tricyclic antidepressant with potent H1 and H2 antagonistic effects. It also has antimuscarinic, antiserotonic, and anti-α-adrenergic activity. Use of 10 to 50 mg PO t.i.d. to q.i.d. has been shown to be effective in the treatment of primary acquired, chronic idiopathic urticaria, idiopathic cold urticaria, and for patients with anxiety or depression associated with their urticaria. Sedation and dry mouth are the most common side effects. Doxepin may interact with other drugs that are metabolized by the cytochrome P-450 system (ketoconazole, itraconazole, erythromycin, clarithromycin, etc.).

Used clinically to treat anxiety and depression. Antidepressant.

2.What is the CAS number for Doxepin hydrochloride ?

The CAS number of Doxepin hydrochloride is 1229-29-4.

More information of Doxepin hydrochloride 1229-29-4 are:

3.What is the molecular formula of Doxepin hydrochloride ?

The chemical formula of?Doxepin hydrochloride is C19H22ClNO which containing 19 Carbon atoms,22 Hydrogen atoms,1 Chlorine atoms,1 Nitrogen atoms and 1 Oxygen atoms,and the molecular weight, and the molecular weight of Doxepin hydrochloride is 315.843

4.What is Doxepin hydrochloride(1229-29-4)used for?

Doxepin is a tricyclic antidepressant that binds to the serotonin (5-HT) transporter (SERT) and norepinephrine transporter (NET; Kds = 68 and 29.5 nM, respectively). It is a histamine H1 receptor antagonist (Ki = 1.23 nM). Doxepin selectively binds to SERT and NET over the dopamine transporter (DAT; Kd = 12,100 nM) and inhibits histamine H1 over H2, H3, and H4 receptors (Kis = 170, 39,810, and 15,135 nM, respectively). It also binds to the 5-HT2 receptor, as well as to muscarinic acetylcholine and α1-adrenergic receptors (α1-ARs; Kds = 27, 23, and 23.5 nM, respectively). Doxepin (10 mg/kg, i.p.) decreases allodynia and hyperalgesia in a mouse model of chronic constriction injury-induced neuropathic pain. It increases the distance traveled in the center of the open field test and reduces immobility time in the forced swim test in a mouse model of depression induced by chronic stress when administered orally at a dose of 15 mg/kg. Formulations containing doxepin have been used in the treatment of depression and insomnia.

InChI:InChI=1/C19H21NO.ClH/c1-20(2)13-7-11-17-16-9-4-3-8-15(16)14-21-19-12-6-5-10-18(17)19;/h3-6,8-12H,7,13-14H2,1-2H3;1H/b17-11+;

Relevant articles related to Doxepin hydrochloride:

5.Buy reliable Quality Doxepin hydrochloride 1229-29-4 raw material with Honest Price

Nantong Advance Chemical Co., Ltd is a quality supplier of Doxepin hydrochloride. Our main goal is customer satisfaction. Contact us to negotiate the best price for your business on Doxepin hydrochloride 1229-29-4.