- Product Name (2S)-N1-[4-Methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl)-4-pyridinyl]-2-thiazolyl]-1,2-pyrrolidinedicarboxamide
- cas 1217486-61-7
- purity 99%
Others
(2S)-N1-[4-Methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl)-4-pyridinyl]-2-thiazolyl]-1,2-pyrrolidinedicarboxamide
Quality products?make an important contribution to long-term revenue and profitability. Factory Export Top Purity (2S)-N1-[4-Methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl)-4-pyridinyl]-2-thiazolyl]-1,2-pyrrolidinedicarboxamide 1217486-61-7 In Stock
1.What is the (2S)-N1-[4-Methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl)-4-pyridinyl]-2-thiazolyl]-1,2-pyrrolidinedicarboxamide ?
(2S)-N1-[4-Methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl)-4-pyridinyl]-2-thiazolyl]-1,2-pyrrolidinedicarboxamide is a newly developed phosphatidylinositol-3-kinase (PI3K) inhibitor and a mTOR inhibitor for the treatment of proliferative diseases.
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![N-(4-methyl-5-(2-(2,2,2-trifluoro-1,1-dimethylethyl)-4-pyridine)-2-thiazole)aminocarbonyl[1H]imidazole ester](/upload/2026/6/580f961eb5254029b4c2247564462447_c9434323-0c68-4bba-a196-de798fe8c79e.png)
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1357476-70-0
N-(4-methyl-5-(2-(2,2,2-trifluoro-1,1-dimethylethyl)-4-pyridine)-2-thiazole)aminocarbonyl[1H]imidazole ester
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7531-52-4
L-prolinamide
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1217486-61-7
alpelisib
Conditions
| Conditions | Yield |
|---|---|
|
With
triethylamine;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 15h;
|
87%
|
|
With
triethylamine;
In
N,N-dimethyl-formamide;
at 20 ℃;
Time;
Inert atmosphere;
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79.6%
|
|
With
triethylamine;
In
N,N-dimethyl-formamide;
for 14h;
Temperature;
Solvent;
Reflux;
Inert atmosphere;
|
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C29 H38 F3 N5 O6 S
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1217486-61-7
alpelisib
Conditions
| Conditions | Yield |
|---|---|
|
With
hydrogenchloride;
In
1,4-dioxane;
at 0 - 20 ℃;
for 1h;
|
92.1%
|
2.What is the CAS number for (2S)-N1-[4-Methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl)-4-pyridinyl]-2-thiazolyl]-1,2-pyrrolidinedicarboxamide ?
The CAS number of (2S)-N1-[4-Methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl)-4-pyridinyl]-2-thiazolyl]-1,2-pyrrolidinedicarboxamide is 1217486-61-7.
More information of (2S)-N1-[4-Methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl)-4-pyridinyl]-2-thiazolyl]-1,2-pyrrolidinedicarboxamide 1217486-61-7 are:
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CAS?Number |
1217486-61-7 |
|
Density |
1.391 |
|
HS CODE |
29341000 |
|
PSA |
129.45000 |
|
LogP |
4.54620 |
|
Pka |
6.29±0.70(Predicted) |
3.What are another words for (2S)-N1-[4-Methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl)-4-pyridinyl]-2-thiazolyl]-1,2-pyrrolidinedicarboxamide ?
Synonyms?for?(2S)-N1-[4-Methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl)-4-pyridinyl]-2-thiazolyl]-1,2-pyrrolidinedicarboxamide 1217486-61-7:(2S)-N1-[4-Methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl)-4-pyridinyl]-2-thiazolyl]-1,2-pyrrolidinedicarboxamide;
4.What is the molecular formula of (2S)-N1-[4-Methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl)-4-pyridinyl]-2-thiazolyl]-1,2-pyrrolidinedicarboxamide?
The chemical formula of ?(2S)-N1-[4-Methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl)-4-pyridinyl]-2-thiazolyl]-1,2-pyrrolidinedicarboxamide is?C19H22F3N5O2S which containing 19 Carbon atoms,22 Hydrogen atoms,3 Fluorine atoms,5 Nitrogen atoms,2 Oxygen atoms and 1 Sulfur atoms,and the molecular weight of??(2S)-N1-[4-Methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl)-4-pyridinyl]-2-thiazolyl]-1,2-pyrrolidinedicarboxamide?is 441.477.
5.What is (2S)-N1-[4-Methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl)-4-pyridinyl]-2-thiazolyl]-1,2-pyrrolidinedicarboxamide (1217486-61-7) used for?
BYL719 is an inhibitor of phosphoinositide 3-kinase α (PI3Kα; IC50s = 4.6, 4, and 4.8 nM for wild-type, E545K mutant, and H1047R mutant PI3K, respectively). It is selective for PI3Kα over PI3Kβ, PI3Kδ, PI3Kγ, and PI4Kβ (IC50s = 1,156, 290, 250, and 581 nM, respectively), as well as VPS34, mTOR, DNA-PK, and ATR (IC50s = >9,100 nM for all). BYL719 (12.5, 25, and 50 mg/kg) reduces tumor volume in a PI3Kα-dependent Rat1-myr-p110α mouse xenograft model. It also reduces tumor burden in THP-1 acute myeloid leukemia (AML) and MCF-7 breast cancer mouse xenograft models. Formulations containing BYL719 have been used in the treatment of advanced or metastatic breast cancer.
Relevant articles related to (2S)-N1-[4-Methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl)-4-pyridinyl]-2-thiazolyl]-1,2-pyrrolidinedicarboxamide:
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Article |
Source |
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Novel synthesis method of PI3K inhibitor Alpelisib |
- Paragraph 0079-0089, (2020/05/05) |
|
Producing Method for 4,4′-oxydianiline from nitrochlorobenzene and nitrophenolate salt |
- Paragraph 0034-0035, (2020/11/10) |
6.Buy (2S)-N1-[4-Methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl)-4-pyridinyl]-2-thiazolyl]-1,2-pyrrolidinedicarboxamide with the best price .
Nantong Advance Chemical Co., Ltd is a quality supplier of (2S)-N1-[4-Methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl)-4-pyridinyl]-2-thiazolyl]-1,2-pyrrolidinedicarboxamide. Our main goal is customer satisfaction. Contact us to negotiate the best price for your business on (2S)-N1-[4-Methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl)-4-pyridinyl]-2-thiazolyl]-1,2-pyrrolidinedicarboxamide 1217486-61-7.
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