Manufacturing Process

A mixture of 250 parts by volume of ethylene glycol, 50 parts by weight of 6- nitro-9-chloro-2-ethoxyacridine (obtained by reaction of 52 parts by weight of 30 nitro-4-ethoxy-diphenylamine-6-carboxylic acid with phosphorous oxychloride), 10 parts by weight of ammonium chloride, and 11 parts by weight of urea were heated to 170°C and stirred for 1 hour at 170°-175°C. Subsequently, the whole was cooled to 100°C, the reaction mixture was introduced into 1000 parts by volume of water, rendered acidic to Congo paper by means of hydrochloric acid and the 6-nitro-9-amino-2-ethoxyacridine precipitated was filtered off. By reduction iron according to Bechamp, 6,9- diamino-2-ethoxy-acridine hydrochloride was obtained with yield of 83% as the yellow needles. The base was prepared by adding an equivalent of NaOH. MP: 124°C.In practice it is usually used as lactate.

Therapeutic Function

Antiseptic, Antibacterial

Safety Profile

Poison by subcutaneous, intraperitoneal, and intravenous routes. Experimental reproductive effects. An antiseptic. When heated to decomposition it emits toxic fumes of NOx.